Solid Phase Extraction Of Biogenic Amines Using Immobilized New Hydrazone Ligands

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dc.contributor.authorAlfergani, Abdassalam Abdelhafiz
dc.date.accessioned2019-10-03T07:05:23Z
dc.date.available2019-10-03T07:05:23Z
dc.date.issued2011-02
dc.description.abstractIn this work, hydrazine and hydrazide compounds were subjected to condensation reaction with ketone and different aldehyde derivatives affording the corresponding expected hydrazones. All the ligands were isolated in satisfactory yields (82 - 94%). Eight hydrazone ligands, namely, benzophenone - 2,4 - dinitrophenylhydrazone (HL1), formaldehyde-2,4–dinitrophenylhydrazone (HL2), salicylaldehyde–2,4– dinitrophenylhydrazone (HL3), 3-hydroxy-4-nitrobenzaldehyde-2,4-dinitrophenylhydrazone (HL4), 3- hydroxy-4-nitrobenzaldehyde-4-hydroxybenzoylhydrazone (HL5), 2-hydroxy-5-nitrobenzaldehyde- 2,4-dinitrophenylhydrazone (HL6), 2-hydroxy-5-nitrobenzaldehyde-4- hydroxybenzoylhydrazone (HL7) and salicylaldehyde-4-hydroxybenzoylhydrazone (HL8) have been synthesized and characterized. Their chemical structures were found to be consistent with both analytical and spectroscopic data (CHN, FTIR, UV/Vis, TGA and 1H NMR). The obtained ligands were evaluated for their anti-microbial activity towards fungi, Aspergillus niger, Aspergillus flavus and Aspergillus fumigatus and bacteria, Staphylooccus sp and Enterobacter sp. The results showed that these compounds are mostly antibacterial rather than antifungal agents.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8924
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectBiogenic Aminesen_US
dc.subjectHydrazone Ligandsen_US
dc.titleSolid Phase Extraction Of Biogenic Amines Using Immobilized New Hydrazone Ligandsen_US
dc.typeThesisen_US
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