Does captopril interrupt compensatory ovarian changes in hemispayed rats
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Date
1999
Authors
Chatterjjee, Rita
Jamalullail, Syed Mohsin Sahil
Chatterjee, Amar
Journal Title
Journal ISSN
Volume Title
Publisher
Kampus Kesihatan, Universiti Sains Malaysia
Abstract
ACE inhibitors are often recommended as the drug of choice to ameliorate essential hypertension. Since the presence of renin-angiotemsin system in the gonadotrophs and the preovulatory follicle might have a link in ovulatory process, our study has been directed to investigate the possible impact of ACE inhibitor, if any, at the pituitary-ovarian system.Experimental research schedule and the findings as presented in the conference and also published are as follows Strictly 4-day cyclic rats were subjected to surgical hemi-spaying on day 1 of the cycle, distributed into four groups and treated with either captopril (ACE inhibitor),captorpirl with prolactin, captopirl with progesterone or the vehicle alone. On the following day 1 of the cycle examination of the fallopian tubes and the ovaries of the animals revealed that 70% of the captopril-treated animals failed to ovulate but maintained compensatory,ovarian hypertrophy (40.9 + 3.00 Vs 32.4 + 2.6 mg). The remaining 30% of the same group of animals although showed the sign of ovulation and compensatory ovarian enlargement (41.8 + 2.2 Vs 32.4 ± 2.6 mg), yet the number of eggs ovulated were found to be extremely low in count (1.6 + 0.1 Vs 12.3+ 0.4).Conversely, the groups of. animals which had either prolactin or progesterone concurrent with captopirl showed conspensatory changes in terms of ovulation and ovarian hypertrophy as documented in the vehicle-treated controls. While angiotensin helps in the synthesis and release of prolactin and the progesterone-primed preovulatory environment of the follicle is prolactin dependent, our findings of captopril induced failure of compensatory ovulation in hemispayed rats suggest that angiotensin converting enzyme inhibitor possibly generates a lesion on the prolactin-progesterone system, an essential system to initiate ovulation.
Description
Keywords
Hemi-spaying , Compensatory ovarian , Captopril(ACE inhibitor) , Hypertrophy , Prolactin , Rats