Does captopril interrupt compensatory ovarian changes in hemispayed rats

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dc.contributor.authorChatterjjee, Rita
dc.contributor.authorJamalullail, Syed Mohsin Sahil
dc.contributor.authorChatterjee, Amar
dc.date.accessioned2018-10-25T03:55:50Z
dc.date.available2018-10-25T03:55:50Z
dc.date.issued1999
dc.description.abstractACE inhibitors are often recommended as the drug of choice to ameliorate essential hypertension. Since the presence of renin-angiotemsin system in the gonadotrophs and the preovulatory follicle might have a link in ovulatory process, our study has been directed to investigate the possible impact of ACE inhibitor, if any, at the pituitary-ovarian system.Experimental research schedule and the findings as presented in the conference and also published are as follows Strictly 4-day cyclic rats were subjected to surgical hemi-spaying on day 1 of the cycle, distributed into four groups and treated with either captopril (ACE inhibitor),captorpirl with prolactin, captopirl with progesterone or the vehicle alone. On the following day 1 of the cycle examination of the fallopian tubes and the ovaries of the animals revealed that 70% of the captopril-treated animals failed to ovulate but maintained compensatory,ovarian hypertrophy (40.9 + 3.00 Vs 32.4 + 2.6 mg). The remaining 30% of the same group of animals although showed the sign of ovulation and compensatory ovarian enlargement (41.8 + 2.2 Vs 32.4 ± 2.6 mg), yet the number of eggs ovulated were found to be extremely low in count (1.6 + 0.1 Vs 12.3+ 0.4).Conversely, the groups of. animals which had either prolactin or progesterone concurrent with captopirl showed conspensatory changes in terms of ovulation and ovarian hypertrophy as documented in the vehicle-treated controls. While angiotensin helps in the synthesis and release of prolactin and the progesterone-primed preovulatory environment of the follicle is prolactin dependent, our findings of captopril induced failure of compensatory ovulation in hemispayed rats suggest that angiotensin converting enzyme inhibitor possibly generates a lesion on the prolactin-progesterone system, an essential system to initiate ovulation.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6889
dc.language.isoenen_US
dc.publisherKampus Kesihatan, Universiti Sains Malaysiaen_US
dc.subjectHemi-spayingen_US
dc.subjectCompensatory ovarianen_US
dc.subjectCaptopril(ACE inhibitor)en_US
dc.subjectHypertrophyen_US
dc.subjectProlactinen_US
dc.subjectRatsen_US
dc.titleDoes captopril interrupt compensatory ovarian changes in hemispayed ratsen_US
dc.typeWorking Paperen_US
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