Analysis of the correlation between mesenchymal-like stem cells and invasiveness of MDA-MB-231 cells.
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Date
2015
Authors
Boon Yin, Khoo
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Abstract
Projek yang membuat hipotesis bahawa sifat invasi sel-sel MDA-MB-231 adalah disebabkan oleh kehadiran sekumpulan sel-sel CD10S+ (sel-sel seperti stem mesenchymal) pada populasi sel-sel kanser ini, telah berjaya mengasingkan sel-sel CD10S+ daripada populasi sel-sel MDA-MB-231 dengan menggunakan MASC Magnetik Menyusun Sel Kit. Projek ini mendapati bahawa pengasingan sel-sel CD10S+ daripada populasi sel-sel MDA-MB-231 tidak mengurangkan kadar pertumbuhan sel-sel kanser ini atau menyebabkan apa-apa kesan apoptosis pada populasi sel-sel ini. This project that hypothesised the invasiveness of MDA-MB-231 is caused by the presence of CD105+ cells (mesenchymal-like stem cells) in the cancer cell population, managed to isolate the CD105+ from the cell population of MDA-MB-231 using the MASC Magnetic Cell Sorting Kit. The project found that removal of the CD105+ cells from the cell population of MDA-MB-231 did not reduce the growth rate or caused any apoptotic effect to the cell population.
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Keywords
mesenchymal , MDA-MB-231 cells , Correlation , Invasiveness