Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
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Date
2009-12
Authors
Lim, Vuanghao
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Colon has been reported as a favourable target site for the systemic absorption of therapeutic protein and peptide drugs, because of its lower peptidase activity, near neutral pH and less hostile conditions as compared with other regions of gastrointestinal tract. The formulated dosage form must pass through the upper gastrointestinal tract in intact form before delivering the drug to the colon. The use of disulphide polymers, a bacteria responsive delivery, is one of the strategies for targeting drugs to the colon and to release drug specifically in the colon. Therefore, the objective of this study was to synthesise a new cross-linked disulphide containing polymer based on amino acid cysteine for colon drug delivery system and to evaluate the polymers under the condition of a low redox potential.
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Keywords
Synthesis And Evaluation Of Cross-Linked Disulphide , Polymers For Colonic Drug