Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery

dc.contributor.author	Lim, Vuanghao
dc.date.accessioned	2018-08-20T00:58:54Z
dc.date.available	2018-08-20T00:58:54Z
dc.date.issued	2009-12
dc.description.abstract	Colon has been reported as a favourable target site for the systemic absorption of therapeutic protein and peptide drugs, because of its lower peptidase activity, near neutral pH and less hostile conditions as compared with other regions of gastrointestinal tract. The formulated dosage form must pass through the upper gastrointestinal tract in intact form before delivering the drug to the colon. The use of disulphide polymers, a bacteria responsive delivery, is one of the strategies for targeting drugs to the colon and to release drug specifically in the colon. Therefore, the objective of this study was to synthesise a new cross-linked disulphide containing polymer based on amino acid cysteine for colon drug delivery system and to evaluate the polymers under the condition of a low redox potential.	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/6360
dc.language.iso	en	en_US
dc.publisher	Universiti Sains Malaysia	en_US
dc.subject	Synthesis And Evaluation Of Cross-Linked Disulphide	en_US
dc.subject	Polymers For Colonic Drug	en_US
dc.title	Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery	en_US
dc.type	Thesis	en_US

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