Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
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Date
2020-05
Authors
Farhan, Ahmed Bassam
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Solid dispersion (SD) formulation has attracted much attention due to its
potential in enhancing dissolution performance of poorly soluble active
pharmaceutical ingredients (API). However, an overview of the dissolution
performance of SDs implies inconsistent degree of dissolution improvement of
poorly soluble APIs in SD. Therefore, the main objective of this study is to
determine the criteria of a good carrier system and drug candidate for enhanced
dissolution performance of a solid dispersion system for a poorly soluble drug and
dosage form consideration particularly the impact of compaction. To achieve these
objectives, several SD systems were prepared in this study by spray drying and
quenched 􀂱cooled methods. To identify the suitability of drug to be formulated in SD
systems, ten different drugs were chosen with different physicochemical properties.
Amorphous form of each drug was prepared using quenched-cooled method.
Theoretical and experimental amorphous advantages were calculated for each drug.
In addition, TGA, ATR-FTIR, contact angle measurement, MD and dissolution
studies were performed. From the results, it was found that these predicating factors
could not be used as a single indicator for predicting dissolution outcome of a solid
dispersion system of poorly soluble drugs. The last part of the thesis involved dosage
form developments of SD systems using two drug candidates that were effective in
SD formulation. Dissolution performances of each SD after compaction was
performed and compared with the corresponding SD-
Description
Keywords
Dissolution Performance , Dispersion Dosage Form