Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form

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dc.contributor.authorFarhan, Ahmed Bassam
dc.date.accessioned2022-03-07T09:02:02Z
dc.date.available2022-03-07T09:02:02Z
dc.date.issued2020-05
dc.description.abstractSolid dispersion (SD) formulation has attracted much attention due to its potential in enhancing dissolution performance of poorly soluble active pharmaceutical ingredients (API). However, an overview of the dissolution performance of SDs implies inconsistent degree of dissolution improvement of poorly soluble APIs in SD. Therefore, the main objective of this study is to determine the criteria of a good carrier system and drug candidate for enhanced dissolution performance of a solid dispersion system for a poorly soluble drug and dosage form consideration particularly the impact of compaction. To achieve these objectives, several SD systems were prepared in this study by spray drying and quenched 􀂱cooled methods. To identify the suitability of drug to be formulated in SD systems, ten different drugs were chosen with different physicochemical properties. Amorphous form of each drug was prepared using quenched-cooled method. Theoretical and experimental amorphous advantages were calculated for each drug. In addition, TGA, ATR-FTIR, contact angle measurement, MD and dissolution studies were performed. From the results, it was found that these predicating factors could not be used as a single indicator for predicting dissolution outcome of a solid dispersion system of poorly soluble drugs. The last part of the thesis involved dosage form developments of SD systems using two drug candidates that were effective in SD formulation. Dissolution performances of each SD after compaction was performed and compared with the corresponding SD-en_US
dc.identifier.urihttp://hdl.handle.net/123456789/14804
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectDissolution Performanceen_US
dc.subjectDispersion Dosage Formen_US
dc.titleInvestigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Formen_US
dc.typeThesisen_US
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