Single-stage biosynthesis of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) using Cupriavidus sp. USMAA1020 via mixed-substrate cultivation strategy.
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Date
2017-03
Authors
Kai Hee, Huong
Journal Title
Journal ISSN
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Publisher
Universiti Sains Malaysia
Abstract
Kopolimer poli(3-hidroksibutirat-ko-4-hidroksibutirat) [P(3HB-ko-4HB)] merupakan polihidroksialkanoat (PHA) yang penting dalam bidang biofarmaseutikal dan perubatan. Produktiviti kopolimer dengan komposisi 4HB yang tinggi sering dicapai melalui pengkulturan dua-peringkat tetapi ini menyukarkan dengan meningkatkan masa dan usaha pengendalian, dan risiko kontaminasi dalam proses penghasilan berskala besar.
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] copolymer is polyhydroxyalkanoate (PHA) with biopharmaceutical and medical significance. Copolymer productivity with high 4HB monomer composition is usually achieved via two-stage cultivation but this reduces the ease of handling by increasing the time, effort and risk of contamination in large-scale production.
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Keywords
Biosynthesis , Cultivation strategy