The role of pulse wave velocity as a marker of severity of coronary artery disease (CAD) in male patients in a single center study
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Date
2009
Authors
ALArhabi, Dr.Ahmed Yahya
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Abstract
Coronary artery disease (CAD) is one of the most common diseases in the world
today, causing 6.9 million deaths worldwide each year, and is the leading cause of
premature death in developed countries. There are many risk factors associated with
increased risk of CAD such as smoking, age, DM, hypercholesterolemia and
hypertension. Early diagnosis and prevention of CAD have stimulated a search for
reliable noninvasive methods of detection. One of the noninvasive test to diagnose
CAD is the detection of arterial stiffness by measuring pulse wave velocity using the
sphygmoCor® machine. This technique is valid, reproducible and widely applied.
The aims of this study was to determine the role of pulse wave velocity (PWV) as a
marker of the severity of CAD as well as to determine the association between PWV
with other cardiovascular risk factors. A cross sectional study with 92 patients
undergoing coronary angiography in ICL HUSM for the assessment of suspected
coronary artery disease was carried out. Arterial stiffness was assessed through left
carotid – right femoral pulse wave velocity using automated SphygmoCor® machine.
The results of this study showed that PWV was higher in patients with CAD than
those without CAD (11.13 ± 0.91 vs 8.14 ± 1.25 m/s, p < 0.001). When the severity
of CAD was expressed as single-, two- and multiple-vessel diseases, there was
significant association between the severity of CAD and PWV (p < 0.05). The
significant independent risk factors of CAD were age and total cholesterol (P < 0.05)
whereas smoking, BMI, SBP, DBP and DM were not significant (P > 0.05). PWV
differed significantly with different categorical severity of CAD even when their age
and total cholesterol were controlled (P < 0.05).
In conclusion, PWV is an independent and complementary cardiovascular risk factor.
Measuring aortic stiffness should serve as marker of end organ damage regarding the
arterial system, indicating an increased risk for cardiovascular complications, and
helps to identify patients at high risk of CAD who may benefit from more aggressive
diagnostic as well as therapeutic strategies.
Description
Master
Keywords
Biological Science , Pulse wave velocity , Coronary artery disease (CAD)