The role of pulse wave velocity as a marker of severity of coronary artery disease (CAD) in male patients in a single center study
| dc.contributor.author | ALArhabi, Dr.Ahmed Yahya | |
| dc.date.accessioned | 2014-11-03T02:20:06Z | |
| dc.date.available | 2014-11-03T02:20:06Z | |
| dc.date.issued | 2009 | |
| dc.description | Master | en_US |
| dc.description.abstract | Coronary artery disease (CAD) is one of the most common diseases in the world today, causing 6.9 million deaths worldwide each year, and is the leading cause of premature death in developed countries. There are many risk factors associated with increased risk of CAD such as smoking, age, DM, hypercholesterolemia and hypertension. Early diagnosis and prevention of CAD have stimulated a search for reliable noninvasive methods of detection. One of the noninvasive test to diagnose CAD is the detection of arterial stiffness by measuring pulse wave velocity using the sphygmoCor® machine. This technique is valid, reproducible and widely applied. The aims of this study was to determine the role of pulse wave velocity (PWV) as a marker of the severity of CAD as well as to determine the association between PWV with other cardiovascular risk factors. A cross sectional study with 92 patients undergoing coronary angiography in ICL HUSM for the assessment of suspected coronary artery disease was carried out. Arterial stiffness was assessed through left carotid – right femoral pulse wave velocity using automated SphygmoCor® machine. The results of this study showed that PWV was higher in patients with CAD than those without CAD (11.13 ± 0.91 vs 8.14 ± 1.25 m/s, p < 0.001). When the severity of CAD was expressed as single-, two- and multiple-vessel diseases, there was significant association between the severity of CAD and PWV (p < 0.05). The significant independent risk factors of CAD were age and total cholesterol (P < 0.05) whereas smoking, BMI, SBP, DBP and DM were not significant (P > 0.05). PWV differed significantly with different categorical severity of CAD even when their age and total cholesterol were controlled (P < 0.05). In conclusion, PWV is an independent and complementary cardiovascular risk factor. Measuring aortic stiffness should serve as marker of end organ damage regarding the arterial system, indicating an increased risk for cardiovascular complications, and helps to identify patients at high risk of CAD who may benefit from more aggressive diagnostic as well as therapeutic strategies. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/271 | |
| dc.language.iso | en | en_US |
| dc.subject | Biological Science | en_US |
| dc.subject | Pulse wave velocity | en_US |
| dc.subject | Coronary artery disease (CAD) | en_US |
| dc.title | The role of pulse wave velocity as a marker of severity of coronary artery disease (CAD) in male patients in a single center study | en_US |
| dc.type | Thesis | en_US |
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