Asymmetric Synthesis Of Cardiovascular Drug Precursor (L-Homophenylalanine) Via Integrated Enzymatic Membrane Bioreactor
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Date
2011-12
Authors
Oh, Pei Ching
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Over the past decade, L-homophenylalanine (L-HPA) is extensively used in the pharmaceutical industry, as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor. which processes significant clinical application in the management of hypertension and congestive heart failure (CHF). A number of chemical methods have been reported thus far for the synthesis of L-HPA. However, chemical methods generally suffer from process complexity, high cost, and environmental pollution. On the other hand, enantiomerically pure L-HPA can be synthesized elegantly and efficiently by employing biocatalytic methods. Where it appears to be the most attractive process in terms of potential industrial applications, green chemistry and sustainability.
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Keywords
Synthesis of cardiovascular drug precursor , via integrated enzymatic membrane bioreactor