Assessment Of Chemotherapy Outcome And Adverse Event Management Among Solid Cancer Patients Of Penang Hospital
Loading...
Date
2013-05
Authors
Hassan, Bassam Abdul Rasool
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
During this century, cancer has become one of the major problem and diseases
which has caused predominant death and will even surpass heart diseases. Both cancer
diseases and chemotherapy have many hazardous side effects which could also affect the
quality of life (QOL) of cancer patients.
Thus this study was performed to detect the main risk factors associated with nausea
and vomiting, anemia, thrombocytopenia and hypercalcemia and to evaluate effectiveness of
respective treatment guidelines. In addition QOL of breast cancer patients with nausea and
vomiting was also evaluated. Prospective and retrospective studies were conducted on solid
cancer patients admitted to Penang, Hospital. Data were collected by using direct person-toperson
interview for the prospective part (nausea and vomiting) and by using specific data
sheet for the retrospective part (anemia, thrombocytopenia and hypercalcemia). The
required data were collected from patients’ files kept in the oncology clinic and the record
office of the hospital.
The prospective study focused on risk factors and QOL of breast cancer patients
(n=158) suffering from nausea and vomiting after chemotherapy administration. These risk
factors include patient's demographic data, breast cancer information, chemotherapy data,
patients’ characteristic data and treatment of nausea and vomiting. The main risk factors
associated with delayed and acute chemotherapy induced nausea and vomiting (CINV) are
patients ethnicity, chemotherapy cycles and types, as well as pre and post antiemetic
treatments used. As for the effect on QOL, delayed CINV has a higher negative effect on
breast cancer patients QOL than acute CINV. Moreover it shows that there is a defect in the
antiemetic treatment guideline which might be due to ethnic variation among the different
races.
Description
Keywords
Chemotherapy Outcome , Solid Cancer Patients