The role of oxidative stress and n-methyl-daspartate receptors in the mechanism of pain modulation in the offspring exposed to prenatal stress
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Date
2019
Authors
Aziz, Che Badariah Abdul
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
An experimental study using thirty-nine pregnant rats was conducted and they were
randomized into three different groups; control, stress group and stress group treated
with antioxidant. The two stress groups were given restraint stress. Antioxidant or
distilled water was given to each of the pregnant dams. The adult off spring were
sacrificed following tonic pain stimulation and their brain and spinal cord were removed
for investigation. The results from the present study have shown that the increased
nociceptive behavior in the prenatally stressed rat offspring was associated with
abnormality in the morphology, level of NMDA receptors and oxidative stress parameters
in the thalamus and spinal cord and the changes were reduced with administration of
antioxidant to the pregnant dams.
Description
Keywords
Prenatal stress