The role of oxidative stress and n-methyl-daspartate receptors in the mechanism of pain modulation in the offspring exposed to prenatal stress

dc.contributor.author	Aziz, Che Badariah Abdul
dc.date.accessioned	2022-02-22T01:31:39Z
dc.date.available	2022-02-22T01:31:39Z
dc.date.issued	2019
dc.description.abstract	An experimental study using thirty-nine pregnant rats was conducted and they were randomized into three different groups; control, stress group and stress group treated with antioxidant. The two stress groups were given restraint stress. Antioxidant or distilled water was given to each of the pregnant dams. The adult off spring were sacrificed following tonic pain stimulation and their brain and spinal cord were removed for investigation. The results from the present study have shown that the increased nociceptive behavior in the prenatally stressed rat offspring was associated with abnormality in the morphology, level of NMDA receptors and oxidative stress parameters in the thalamus and spinal cord and the changes were reduced with administration of antioxidant to the pregnant dams.	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/14727
dc.language.iso	en	en_US
dc.publisher	Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia	en_US
dc.subject	Prenatal stress	en_US
dc.title	The role of oxidative stress and n-methyl-daspartate receptors in the mechanism of pain modulation in the offspring exposed to prenatal stress	en_US
dc.type	Other	en_US

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