Influence of steptozotocin- induced diabetes on cardiovascular responses to intrathecal administration of neurotransmitiers
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Date
1994
Authors
Abugama, Magub Abdullah
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Journal ISSN
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Abstract
_Diabetes Mellitus is often associated with cardiovascular dysfunction. _Impaired
autonomic reflex control of the cardiovascular system is a common feature.
However the nature of sympathetic dysfunction in this condition has not been
wdl examined. In this study the effects of activating the cells in the
intermediolateral cell column (Th1L) of the spinal cord on blood pressure and
heart rate of nonnal and chemically induced diabetic rats were investgatecL
Diabetes was induced with streptozotocin (65mglkg, I. V) in fasted male Sprague
Dawley rats and different parameters were recorded in a comprehensive study to
obtain a good diabetic animal model.
Groups of diabetic rats were treated with Andrographis paniculata ( H empedu
Bumi ), a plant which is reputed to be beneficial for the treatment of diabetes.
)irect blood pressure and heart rate were recorded and changes in responses to
ntrathecally administered glutamate, 5-hydroxytryptamine, vasopressm,
;ubstance P.. adrenaline and neuropeptide Y noted. Diabetic rats were hypotensive
md had lower heart rates compared with control rats. Blood pressure responses to
ransmitters were depressed whilst heart rates responses were variable.
t il!<•'"
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~0 further series of experiments, the effects of one of the neurotransmitters,
¢Jy. Vasopressin, were tested in diabetic rats treated with the plant. The
~~tt exrract appeared to be capable of reversing the diabetic effects towards
control values.
.
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Keywords
Steptozotoci , Cardiovascular responses , Neurotransmitiers