Behavioural, Biochemical, Proteomics Studies And Replacement Therapy Of Morphine And Mitragynine Withdrawal Rat Models
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Date
2021-01
Authors
Hassan, Rahimah
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The current study was designed to test the ability of mitragynine to attenuate behavioural signs of morphine-withdrawal in a rat model in comparison to methadone and buprenorphine. A six-day treatment with escalating dose of morphine (10-50 mg/kg, i.p.) induced profound withdrawal signs for 16 days.
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Keywords
Behavioural , Biochemical , Proteomics , Replacement Therapy Of Morphine , Withdrawal Rat Models