Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma

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dc.contributor.authorAisha, Abdalrahim F. A.
dc.date.accessioned2018-12-11T06:29:00Z
dc.date.available2018-12-11T06:29:00Z
dc.date.issued2011-12
dc.description.abstractThis study aims to investigate the of the anti-angiogenic and anti-colon cancer activity extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solubility. Phytochemical analysis of S. campanulatum extracts reveals relatively high concentration of betulinic acid (BA) and polyphenols. BA fraction from S. campanulatum showed potent cytotoxicity on colon cancer cells by inducting the mitochondrial pathway of apoptosis. Extracts also showed potent inhibition of angiogenesis in several in vitro and in vivo models, by inhibiting the expression of vascular endothelial growth factor and inhibiting migration of human endothelial cells. The methanolic extract also inhibits tumor growth in xenograft tumor model with inhibition of intratumor blood vessels. α- and γ-mangostin were isolated from G. mangostana fruit rinds, and were used to standardize the G. mangostana extracts by UV spectrophotometric and HPLC methods. The isolates and the xanthone extracts demonstrated potent cytotoxicity on colon cancer cells by inducing the mitochondrial apoptosis pathway, and also showed effective in vitro anti tumorigenicity. The compounds induced the transcription factor activity of p53, Myc/Max and MAPK/ERK signaling pathways and inhibit the NF-KB pathway. The toluene extract of G. mangostana showed significant delayed onset inhibition of tumor growth in vivo. S. campanulatum and G. mangostana extracts did not show severe toxic effects and the LD50 in Sprague Dawley rats was more than 2000 mg/kg body weight. Cationic nanoparticles of G. mangostana toluene extract were prepared by the nanoprecipitation method in Eudragit polymers RL100 and RS100. Particle size was below 70 nm with high entrapment efficiency (>90%).en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7257
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectThe anti-angiogenic and anti-colon canceren_US
dc.subjectisolates of Syzygium campanulatumen_US
dc.titleAnti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinomaen_US
dc.typeThesisen_US
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