Effects Of High Salt Load On Renal Hemodynamics And Function In Normotension And Hypertension: Role Of Alpha 1-Adrenoceptor
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Date
2011-03
Authors
Ahmed Kazi, Raisa Nazir
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Hypertension is a major cause of coronary heart disease, renal failure and stroke.
Sodium plays an important pathophysiological role in the development of
hypertension. The renal adrenergic system contributes to the hypertensive effect of
sodium loading. The aim of this study was to investigate whether elevated dietary
sodium intake had any effect on the mean arterial blood pressure (MAP) and renal
cortical vascular reactivity to adrenergic stimuli in terms of its relation to α1-
adrenergic mechanism. Further this study aimed to identify the contribution of α1-
adrenoreceptor subtypes in the regulation of renal cortical hemodynamic and renal
tubular functions in both normotensive WKY (Wistar Kyoto rat) and SHR
(spontaneously hypertensive rats) subjected to high sodium load. Both SHR and
WKY rats were kept on normal (WKYNNa & SHRNNa) and high sodium diet
(WKYHNa & SHRHNa) for six weeks and the metabolic data collected. The
animals were housed individually in custom-built stainless steel metabolic cages;
baseline data were determined followed by experimental data collection for six
consecutive weeks. Weekly blood and urine samples were collected, and body
weight, 24-h water intake and 24-h urine output were measured.
Description
Keywords
High Salt Load , Alpha 1-Adrenoceptor