Effects Of High Salt Load On Renal Hemodynamics And Function In Normotension And Hypertension: Role Of Alpha 1-Adrenoceptor

Loading...
Thumbnail Image
Date
2011-03
Authors
Ahmed Kazi, Raisa Nazir
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Hypertension is a major cause of coronary heart disease, renal failure and stroke. Sodium plays an important pathophysiological role in the development of hypertension. The renal adrenergic system contributes to the hypertensive effect of sodium loading. The aim of this study was to investigate whether elevated dietary sodium intake had any effect on the mean arterial blood pressure (MAP) and renal cortical vascular reactivity to adrenergic stimuli in terms of its relation to α1- adrenergic mechanism. Further this study aimed to identify the contribution of α1- adrenoreceptor subtypes in the regulation of renal cortical hemodynamic and renal tubular functions in both normotensive WKY (Wistar Kyoto rat) and SHR (spontaneously hypertensive rats) subjected to high sodium load. Both SHR and WKY rats were kept on normal (WKYNNa & SHRNNa) and high sodium diet (WKYHNa & SHRHNa) for six weeks and the metabolic data collected. The animals were housed individually in custom-built stainless steel metabolic cages; baseline data were determined followed by experimental data collection for six consecutive weeks. Weekly blood and urine samples were collected, and body weight, 24-h water intake and 24-h urine output were measured.
Description
Keywords
High Salt Load , Alpha 1-Adrenoceptor
Citation