Effects Of High Salt Load On Renal Hemodynamics And Function In Normotension And Hypertension: Role Of Alpha 1-Adrenoceptor

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dc.contributor.authorAhmed Kazi, Raisa Nazir
dc.date.accessioned2019-10-04T02:29:07Z
dc.date.available2019-10-04T02:29:07Z
dc.date.issued2011-03
dc.description.abstractHypertension is a major cause of coronary heart disease, renal failure and stroke. Sodium plays an important pathophysiological role in the development of hypertension. The renal adrenergic system contributes to the hypertensive effect of sodium loading. The aim of this study was to investigate whether elevated dietary sodium intake had any effect on the mean arterial blood pressure (MAP) and renal cortical vascular reactivity to adrenergic stimuli in terms of its relation to α1- adrenergic mechanism. Further this study aimed to identify the contribution of α1- adrenoreceptor subtypes in the regulation of renal cortical hemodynamic and renal tubular functions in both normotensive WKY (Wistar Kyoto rat) and SHR (spontaneously hypertensive rats) subjected to high sodium load. Both SHR and WKY rats were kept on normal (WKYNNa & SHRNNa) and high sodium diet (WKYHNa & SHRHNa) for six weeks and the metabolic data collected. The animals were housed individually in custom-built stainless steel metabolic cages; baseline data were determined followed by experimental data collection for six consecutive weeks. Weekly blood and urine samples were collected, and body weight, 24-h water intake and 24-h urine output were measured.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8943
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectHigh Salt Loaden_US
dc.subjectAlpha 1-Adrenoceptoren_US
dc.titleEffects Of High Salt Load On Renal Hemodynamics And Function In Normotension And Hypertension: Role Of Alpha 1-Adrenoceptoren_US
dc.typeThesisen_US
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