A PRELIMINARY (PILOT) STUDY ON CYTOCHROME P450 2D6 POLYMORPHISM IN CHRONIC PAIN.
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Date
2012
Authors
Azlan Sani, Shamsuddin
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Introduction: There were studies done on cytochrome P450 2D6 polymorphism in many
diseases. However there is no study investigating its polymorphism in chronic pain patients.
Thus, this pilot study is to get baseline data for further larger study.
Objectives: To investigate the genetic polymorphism pattern of cytochrome P450 2D6
among chronic pain patient.
Methodology: After ethical committee approval, a pilot, descriptive cross-sectional study
was conducted on 40 chronic pain patients. They were divided into cancer and noncancer
groups. About 5ml of venous blood was sampled from each patient and sent for genotyping
of CYP 2D6 polymorphism. Their demographic data and VAS score were recorded.
Result: We found that the commonest CYP2D6 genotype was CYP2D6 *1/*10 (35%). The
majority of them were EM (67.5%) and 22.5% were IM but none was PM. The nociceptive
pain was more common type of pain among cancer pain patients.
Conclusion: The genetic polymorphism patterns of CYP2D6 were highly polymorphic
among chronic pain patient and the dose modification of analgesics drugs may influence the
therapeutic outcome and satisfaction.
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Keywords
Anesthesiology