A PRELIMINARY (PILOT) STUDY ON CYTOCHROME P450 2D6 POLYMORPHISM IN CHRONIC PAIN.

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dc.contributor.authorAzlan Sani, Shamsuddin
dc.date.accessioned2017-10-29T02:13:00Z
dc.date.available2017-10-29T02:13:00Z
dc.date.issued2012
dc.description.abstractIntroduction: There were studies done on cytochrome P450 2D6 polymorphism in many diseases. However there is no study investigating its polymorphism in chronic pain patients. Thus, this pilot study is to get baseline data for further larger study. Objectives: To investigate the genetic polymorphism pattern of cytochrome P450 2D6 among chronic pain patient. Methodology: After ethical committee approval, a pilot, descriptive cross-sectional study was conducted on 40 chronic pain patients. They were divided into cancer and noncancer groups. About 5ml of venous blood was sampled from each patient and sent for genotyping of CYP 2D6 polymorphism. Their demographic data and VAS score were recorded. Result: We found that the commonest CYP2D6 genotype was CYP2D6 *1/*10 (35%). The majority of them were EM (67.5%) and 22.5% were IM but none was PM. The nociceptive pain was more common type of pain among cancer pain patients. Conclusion: The genetic polymorphism patterns of CYP2D6 were highly polymorphic among chronic pain patient and the dose modification of analgesics drugs may influence the therapeutic outcome and satisfaction.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5135
dc.language.isoenen_US
dc.publisherPusat Pengajian Sains Perubatan Universiti Sains Malaysiaen_US
dc.subjectAnesthesiologyen_US
dc.titleA PRELIMINARY (PILOT) STUDY ON CYTOCHROME P450 2D6 POLYMORPHISM IN CHRONIC PAIN.en_US
dc.typeThesisen_US
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