OCULAR BIOMETRY, OPTIC NERVE HEAD PARAMETERS AND RETINAL NERVE FIBER LAYER THICKNESS IN SEVERE PRETERM MALAY CHILDREN
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Date
2012-03
Authors
ALSHAARAWI, M.A. SALEM
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Introduction: Severe preterm delivery is defined as babies born at 32 weeks or less of
gestation. The earlier the baby is born, the less likely he or she is to survive. Those who
do survive are at a higher risk of lifelong health problems, of which the ophthalmic
complications include retinopathy of prematurity, myopia, amblyobia, strabismus and
optic nerve abnormalities.
Objective : This study is to compare the ocular biometric parameters, optic nerve
head parameters, and retinal nerve fiber layer thickness parameters between severe
preterm and term Malay children aged 8-16 years old.
Methodology: This comparison cross sectional study evaluated 64 patients, 32 patients
were born less than 32 weeks of gestation and 32 patients were full term. All patients
underwent thorough eye examination. Ocular biometry was performed using A- Scan
ultrasound biometry, whilst optic nerve head parameters and retinal nerve fiber layer
thickness were performed using Heidelberg Retinal Tomograph III.
Results: There was a statistically shorter vitreous chamber depth between severe
preterm group and term group, (p=0.04). However, there was no statistically significant
difference of anterior chamber depth, lens thickness and axial length between severe
preterm group and term group. The rim volume, cup shape measurement, height
variation contour, and mean cup depth in severe preterm group were statistically
increased compared to the term group and (p<0.05). However, the mean cup area,
cup/disc, cup volume, mean rim area, cup/disc area, linear cup/disc area and maximum
cup depth between severe preterm group and term group were not statistically
significant (p>0.05). The mean nasal quadrant of retinal nerve fiber layer is significantly
thinner in severe preterm children, whilst global retinal nerve fiber layer of
nasal/superior quadrant and nasal/inferior quadrant are significantly thicker in severe
preterm compared to term children. On the other hand, no significant differences have
been reported in temporal quadrant, temporal/superior, and temporal/inferior quadrant
between severe preterm group and term group (p>0.05).
Conclusion: This study shows the vitreous chamber is significantly shorter in severe
preterm children. The rim volume, cup volume, cup shape measurement, height
variation contour and mean cup depth of optic nerve head are significantly different
between severe preterm and term children.
Description
Keywords
CLINICAL OPHTHALMOLOGY