Synthesis And Characterisation Of Mesoporous Hydroxyapatite Bioceramics
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Date
2011-09
Authors
Lew, Kien Seng
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Mesoporous hydroxyapatite (HA) with smaller pore size in the nano range
and with narrower pore size distribution is a better candidate to provide a more
favourable drug release profile by exhibiting a more uniform and sustained release.
This research was conducted to investigate the drug impregnation and release
capability of mesoporous HA synthesised via a self-assembly mechanism between
HA and cationic surfactant decyltrimethylammonium bromide (C10TAB) through a
co-precipitation route. Different parameters such as pH-control technique, ageing
duration, and water ratio were attempted during the synthesis to investigate their
respective influence on the sorption properties. Various characterisations techniques
including x-ray diffraction, nitrogen gas adsorption and scanning electron
microscopy were carried out to examine the structure and pore characteristics of the
mesoporous HA. It was found that the combination of parameters which rendered the
best pore characteristics and sorption properties consisted of water ratio (C10TABphosphate
and calcium solution) of 140 : 20 ml with continuous pH-control and 24-
hour ageing. Using these parameters, a phase-pure HA with pore width 2 – 6 nm and
surface area 73.3 m2/g was synthesised. An in vitro drug delivery test was also
conducted using ibuprofen as a drug and mesoporous HA as a carrier. The
mesoporous HA showed a drug impregnation capacity of 45.48 mg/g and was able to
release drug continuously for 52 hours. In addition, mesoporous HA in the form of
spherical granules with diameter 1 – 25 Im were also successfully produced through
a spray-drying method.
Description
Keywords
Synthesis and characterisation of , mesoporous hydroxyapatite bioceramics