Synthesis And Characterisation Of Mesoporous Hydroxyapatite Bioceramics
| dc.contributor.author | Lew, Kien Seng | |
| dc.date.accessioned | 2018-12-03T07:14:35Z | |
| dc.date.available | 2018-12-03T07:14:35Z | |
| dc.date.issued | 2011-09 | |
| dc.description.abstract | Mesoporous hydroxyapatite (HA) with smaller pore size in the nano range and with narrower pore size distribution is a better candidate to provide a more favourable drug release profile by exhibiting a more uniform and sustained release. This research was conducted to investigate the drug impregnation and release capability of mesoporous HA synthesised via a self-assembly mechanism between HA and cationic surfactant decyltrimethylammonium bromide (C10TAB) through a co-precipitation route. Different parameters such as pH-control technique, ageing duration, and water ratio were attempted during the synthesis to investigate their respective influence on the sorption properties. Various characterisations techniques including x-ray diffraction, nitrogen gas adsorption and scanning electron microscopy were carried out to examine the structure and pore characteristics of the mesoporous HA. It was found that the combination of parameters which rendered the best pore characteristics and sorption properties consisted of water ratio (C10TABphosphate and calcium solution) of 140 : 20 ml with continuous pH-control and 24- hour ageing. Using these parameters, a phase-pure HA with pore width 2 – 6 nm and surface area 73.3 m2/g was synthesised. An in vitro drug delivery test was also conducted using ibuprofen as a drug and mesoporous HA as a carrier. The mesoporous HA showed a drug impregnation capacity of 45.48 mg/g and was able to release drug continuously for 52 hours. In addition, mesoporous HA in the form of spherical granules with diameter 1 – 25 Im were also successfully produced through a spray-drying method. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/7175 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Synthesis and characterisation of | en_US |
| dc.subject | mesoporous hydroxyapatite bioceramics | en_US |
| dc.title | Synthesis And Characterisation Of Mesoporous Hydroxyapatite Bioceramics | en_US |
| dc.type | Thesis | en_US |
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