Phytochemical And Biological Investigation On Three Species Of The Genus Homalomena

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dc.contributor.author., Abdul Hamid
dc.date.accessioned2019-01-31T01:59:54Z
dc.date.available2019-01-31T01:59:54Z
dc.date.issued2011-11
dc.description.abstractThree species from the genus Homalomena, namely, H. pineodora, H. sagittifolia and H. coerulescens were chosen for this particular research since they have long been used in traditional medicine. The essential oils of the leaves and rhizomes of the three species were isolated by hydrodistillation and analyzed by capillary GC and GC-MS, utilizing two columns of different polarities. Isolation and purification of non-volatile phytochemicals were carried out using various solvent systems and chromatographic methods and their structures were determined by using spectroscopic methods such as FT-IR, one and two dimensional NMR experiments: 1H-NMR, 13C-NMR, DEPT 45, DEPT 90, DEPT 135, 1H-1H-COSY, 1H-1H-NOESY, 1H-13C-HMQC, 1H-13C-HMBC, GC-MS, DP-MS and LR-MS. The essential oils, crude extracts and some of the isolated compounds were assayed for biological activity (antibacterial, acetylcholinesterase enzyme inhibitory activity and anti-inflammatory activity) to evaluate their reported traditional uses. The leaf and rhizome oils of H. pineodora contain high levels of non-terpenoid compounds, particularly, (E)-tridec-2-en-4-one (47.5%) and 2-hydroxy-4-tridecanone (29.5%), and these were isolated by using preparative GC and their structures were established by means of spectral interpretation and confirmed by comparing their spectral data with those of authentic standards. In addition, two constituents, tridec-1- en-4-one and tridecane-2, 4-dione of H. pineodora were also identified by synthesis. The essential oils of H. sagittifolia and H. coerulescens were dominated by monoterpenoids. β-Pinene (16.5 % ) and linalol (34.5 %) were the major constituents of the rhizome oil, while α-pinene (50.1 %) and β-pinene (24.1 % ) were predominant in leaf oil of H. sagittifolia. In H. coerulescens, the main chemical component in the rhizome oil was linalool (37.2 %), while in the leaf oil α- pinene (34.3%) and β- pinene (24.9%) were predominant.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7698
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectPhytochemical and biological investigationen_US
dc.subjectthree species of the genus Homalomenaen_US
dc.titlePhytochemical And Biological Investigation On Three Species Of The Genus Homalomenaen_US
dc.typeThesisen_US
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