Quality Of Stored Cord Blood In National Blood Centre Based On Maternal And Neonatal Factors
| dc.contributor.author | Azmi, Nor Azhani | |
| dc.date.accessioned | 2018-05-24T02:33:53Z | |
| dc.date.available | 2018-05-24T02:33:53Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Background: Umbilical cord blood (UCB) is an alternative source of allogeneic haematopoietic stem cells for transplantation. The quality of collected UCB depends on its haematopoietic content which directly influences the engraftment and the therapeutic outcome. To ensure the quality of stored UCB, the acceptance criteria were created at the UCB bank in National Blood Centre (NBC) based on established international standard, which resulted in a high discard rate. This study aims to determine the association of maternal and neonatal factors that could influence the quality of haematopoietic contents of the UCB collections thus guide the choice of donors and reduce wastage. Methods/Design: This is a retrospective cross-sectional study performed by reviewing records of 339 cord blood donations which were successfully cryopreserved in 2014 at the NBC, Malaysia. The data on stored UCB analysed were the UCB volume, total nucleated cell (TNC) count, CD34+ cells concentration, and colony forming units (CFU). The maternal factors analysed were age, race, gravid status, gestational period and blood group while the neonatal characteristics included gender, neonatal birth weight and blood group. One-way ANOVA, independent t-test, Pearson correlation, and single linear regression were used to determine the association between the factors and the haematopoietic contents of the UCB collected. Results: Based on the NBC report, 39% (692) of the total UCB collected (1781) in 2014 met the acceptance criteria and stored. Low TNC and low UCB volume accounted for the highest reasons for UCB discard. Analysis of the maternal and neonatal factors showed that gestational age has a weak negative correlation with UCB volume (r= -0.182, p=0.001). While neonatal birth weight, is significant but showed weak correlation with CB volume (r=0.174, p=0.001) and TNC count/unit (r=0.116, p=0.034). Haematopoietic contents are all interrelated; the UCB volume with TNC count/unit (r=0.594, p<0.001), UCB volume with CD34+/unit (r=0.364, p<0.001) and UCB volume with CFU (r=0.177, p< 0.015). Conclusions: This study concluded that maternal and neonatal factors were associated with the UCB haematopoietic contents. The factors identified were gestational age of the mother and new born weight which had significant association with the UCB volume and TNC count. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/5584 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Umbilical cord blood, donation, cord blood banking | en_US |
| dc.subject | maternal and neonatal factors | en_US |
| dc.title | Quality Of Stored Cord Blood In National Blood Centre Based On Maternal And Neonatal Factors | en_US |
| dc.type | Thesis | en_US |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: