Evaluation Of Andrographis Paniculata, Eurycoma Longifolia And Phyllagathis Rotundifolia For Antimalarial Activity Against Chloroquine And Mefloquine Resistant Malarial Parasites

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dc.contributor.authorChe Husin, Che Nasriyyah
dc.date.accessioned2018-09-19T01:58:29Z
dc.date.available2018-09-19T01:58:29Z
dc.date.issued2010-07
dc.description.abstractThe emergence of drug resistant malaria parasite is one of the major health problems in the world and the search for new treatment is increasingly becoming a priority. Plants remained an important natural source of health remedy for mankind. However, scientific evidence is crucial to support claims of health benefits. The objectives of this study firstly to determine the antimalarial activity of Andrographis paniculata (A. paniculata) against chloroquine (CQ) and mefloquine (MQ) resistant Plasmodium falciparum (P. falciparum) strain and their efficacy in combination with CQ or MQ. Secondly to study the efficacy of A. paniculata and E. longifolia in combination with CQ against CQ resistant Plasmodium berghei (P. berghei). Lastly to determine the effect of water and ethanol extract of Phyllagathis rotundifolia (P. rotundifolia) on P. berghei (CQ and MQ resistant strain). P. falciparum Dd2 strain was cultured and in vitro assays were done with various concentrations of CQ and MQ individually and in combination with various concentrations of A. paniculata. Parasites were labeled with 3H-hypoxanthine and incorporation of radiolabeled isotope was determined. The 50% inhibitory concentration (IC50) values of CQ, MQ, A. paniculata and various combination of CQ-A. paniculata and MQ-A. paniculata were determined by probit analysis and isobologram.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6587
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectAndrographis Paniculata, Eurycoma Longifolia And Phyllagathis Rotundifoliaen_US
dc.subjectChloroquine And Mefloquine Resistant Malarial Parasitesen_US
dc.titleEvaluation Of Andrographis Paniculata, Eurycoma Longifolia And Phyllagathis Rotundifolia For Antimalarial Activity Against Chloroquine And Mefloquine Resistant Malarial Parasitesen_US
dc.typeThesisen_US
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