Distribution of allele frequencies of short tandem repeats (strs), d16S539, D13S317 and D7S820 in Kadazan population group in Sabah, Malaysia
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Date
2008
Authors
Kit, Gabriel Loh Onn
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
Abstract
Polymerase Chain Reaction (PCR) based Short Tandem Repeat (STR) DNA
profiling has revolutionized forensic human identification and individualization. The STR
DNA profiling provides certainty in human identification because of the markers having
high heterozygosities and discrimination power probability. The distribution of STR
alleles utilize in DNA profiling that is between populations. For application of STR DNA
profiling in kinship testing, it is essential to have a population database for individual
ethnic groups. With this objective in this research study, the population database for three
validated STR namely D7S820, Dl3S317 and Dl6S539 for Kadazan population Eastem
Malaysia was compiled. The heterozygosities (H) for these three STR are D7S820
(0.9136), D13S317 (0.9152) and Dl6S539 (0.9283). Power of discrimination (PD) for
these three STR are D7S820 (0.9226), Dl3S317 (0.9152) and Dl6S539 (0.9283). The
cumulative discrimination power (CDP) for these three STR for Kadazan population is
0.9995. This database can be used in criminal cases and kinship testing in Kadazan
population involving individual.
Description
Keywords
DNA