Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients

dc.contributor.author	Bebakar, Wan Mohamad Wan
dc.date.accessioned	2019-07-17T04:26:09Z
dc.date.available	2019-07-17T04:26:09Z
dc.date.issued	2003
dc.description.abstract	Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycaemia and dyslipidaemia, which places diabetics at increased risk of cardiovascular disease. We strongly believed that LDL cholesterol (LDLC), triglycerides (TG) and apolipoprotein E (apo E) genotype are closely related in determining this high risk. This study aims to study the effect of LDL subfraction and apo E genotype on diabetic dyslipidaemia. Normal (n=30) and diabetes mellitus type 2 (n=35) subjects who were not on any drug treatment were studied. Lipid biochemical analysis was performed by automated methods using commercial kits. LDL size was determined by transmission electron microscopy. LDLI and LDL2 are large panicles while LDL3, LDL4, and LDL5 are smaller particles and are considered detrimental to health. Apo E genotype was determined by polymerase chain reaction and restric tion fragment length polymorphism.	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/8519
dc.language.iso	en	en_US
dc.publisher	Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia	en_US
dc.subject	diabetes	en_US
dc.title	Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients	en_US
dc.type	Thesis	en_US

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