Molecularly Imprinted Polymer Basedmicro- Solid Phase Extraction Of Bisphenol A And Sulfonamide Antiobiotics In Aqueous Samples
| dc.contributor.author | Rozaini, Muhammad Nur’ Hafiz | |
| dc.date.accessioned | 2019-01-31T06:59:13Z | |
| dc.date.available | 2019-01-31T06:59:13Z | |
| dc.date.issued | 2018-02 | |
| dc.description.abstract | This thesis focuses on the development, validation and application of new sample preparation methods for the determination of bisphenol A (BPA) and sulfonamide antibiotics (SAs) in aqueous matrices. A rapid microextraction method based on ultrasound-assisted emulsification micro-solid phase extraction incorporated with molecularly imprinted polymer (USAE-MIP-μ-SPE) was developed for the determination of BPA in water, beverages and the aqueous liquid in canned foods prior to high performance liquid chromatography diode array detector (HPLC-DAD). Under the optimized conditions, USAE-MIP-μ-SPE showed a good linearity over a concentration range of 0.5–700 μg L-1 low limit of detection (0.07 μg L-1), good analyte recoveries (82.2–118.9 %) and acceptable repeatability (RSD=0.7–14.2 %, n=3) with the enrichment factor of 49. The developed method demonstrated good selectivity and reusability for extraction of BPA and hence, the USAE-MIP-μ-SPE is simple, rapid, inexpensive and environmentally friendly. A facile mixed matrix membrane microextraction based on molecularly imprinted silica gel sorbent (MISG-MMMM) was developed for the determination of three selected sulfonamide antibiotics in water samples. The molecularly imprinted silica gel (MISG) was prepared by a surface imprinting technique with a sol-gel process. MISG-MMMM method demonstrated good limit of detection, in the ranges of 0.06– 0.17 μg L-1 for sulfamethoxazole, sulfadiazine and sulfamonomethoxine with a good linearity (R2≥0.995) in the concentration of 1–500 μg L-1, good recoveries (80- 96%) and repeatability (RSD = 1.0–7.2, n=3). MISG-MMMM avoids tedious extraction operations and requires minute amount of solvent (200 μL) and sorbent (15 mg). MISG–MMMM is beneficial in term of simplicity, ease of operation and delivers significant cost advantages. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/7706 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Polymer based-micro-solid phase extraction of bisphenol A | en_US |
| dc.subject | sulfonamide antibiotics in aqueous samples | en_US |
| dc.title | Molecularly Imprinted Polymer Basedmicro- Solid Phase Extraction Of Bisphenol A And Sulfonamide Antiobiotics In Aqueous Samples | en_US |
| dc.type | Thesis | en_US |
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