Immunofenotype mononucleus cell peripheral malaria patients
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Date
1999
Authors
Nor, Norazmi Mohd
Jamaluddin, Normah
Journal Title
Journal ISSN
Volume Title
Publisher
Kampus Kesihatan, Universiti Sains Malaysia
Abstract
The absolute number and percentage of various T cell subsets in patients with acute malaria infection was investigate with special reference to the expression of the T activation markers, CD25,HLA-DR and CD38. The absolute number but not the percentage of CD4+(p<0.001) and CD8 (p<0.02) T cell subsets as well as total B cells (CD19+) (p<0.02) was reduced in these patients. In contrast, the percentage of T cells bearing the gamma-delta (gd) T-cell receptor (TCR) was significantly increased (p<0.02). Although the expression of CD25 on any of the T cell subsets with the normal range, increases in the percentage of CD8+CD38 + (p<0.005) gd+HLA-DR+ (p<0.001) and gd+CD38+ (p<0.005) T cell subsets may be suggestive inter-relationship with the disease the significant of which remains to of their be ascertained.
Description
Keywords
CD4 cell , CD8 cell , Gamma-delta cell , Acute malaria infection