Effects Of Tualang Honey On Reproductive System And Bone Properties In Ovariectomised Rats
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Date
2011-05
Authors
Mohamad Zaid, Siti Sarah
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Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Honey is a highly nutritional natural product that has been widely used in the folk medicine for a number of therapeutic purposes. In this study, Tualang honey was evaluated for its effectiveness in reducing postmenopausal changes in bilaterally ovariectomised rats. In study I (short term two weeks study), rats were randomly divided into five groups (n=7), which were the of sham control group (SHAM), ovariectomised control group (OVX), THL ovariectomised group (received 0.2 g/kg of Tualang honey), THM ovariectomised group (received 1.0 g/kg of Tualang honey) and THH ovariectomised group (received 2.0 g/kg of Tualang honey). Both SHAM and OVX groups received 0.5 ml vehicle treatment of distilled water. The treatment was given orally by gavage daily for two weeks. The reproductive organs (uterus and vagina) and tibia bone were subjected to histopathological examination while the serum was for hormonal assays. Administration of Tualang honey for two weeks to ovariectomised rats significantly increased the weight of the uterus and vagina (P<0.05), increased the thickness of vaginal epithelium and muscular layers (P<0.05), increased the thickness of uterine endometrium and myometrium layers (P<0.05), restored the thickness of trabecular tibia bone and suppressed the body weight (P<0.05) compared to OVX group.
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Keywords
Tualang Honey , Reproductive System