In Vitro Effect Of Malaysian Mikania Cordata Leaves Extract On Blood Coagulation Factors Level In Plasma

Simple item page
dc.contributor.authorYusoff, Nur Yuzaiza
dc.date.accessioned2017-10-06T06:50:31Z
dc.date.available2017-10-06T06:50:31Z
dc.date.issued2016
dc.description.abstractCurrent anticoagulant agent such as warfarin and heparin have demonstrated lifethreatening side effect and its efficacy also been doubted. So, exploration of herbal plant been done and one of them is Mikania cordata. Mikania cordata (Bum. F.) B.L Robinson or commonly called selaput tunggul, in Malaysia, belongs to family of Asteraceae and it was claimed to prolonged PT (prothrombin time), APTT (activated partial thromboplastin time) and TT (thrombin time) in early study. Thus, aim in this study were to identify the active compound through GCMS analysis and to determine level of factors VII, IX, X, II and FGN in plasma treated in vitro with different concentrations of M.cordata aqueous leaves extract. As a result, in 25.0 mg/ml of M. cordata extract, significant percentage of factor reduced can be observed which were in FII with 90.17%, followed by FGN (89.80%), FX (80.91%), FIX (69.15%) and finally FVII (62.67%) compared to control with p < 0.001.This finding was supported by the identification of malic acid which was believed to possess anticoagulant activity. Malic acid also reacts in concentration- dependent manner when 25.0 mg/ml of M. cordata extract treated on plasma showed high reduction of factors compared to 12. 5 mg/ml. In conclusion, it was confirmed that malic acid possess anticoagulant activity in concentration dependent manner, by reducing level of factors VII, IX, X, FII and FGN in plasma.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4831
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectMikania Cordata Leaves Extract Onen_US
dc.subjectBlood Coagulation Factors Level In Plasmaen_US
dc.titleIn Vitro Effect Of Malaysian Mikania Cordata Leaves Extract On Blood Coagulation Factors Level In Plasmaen_US
dc.typeThesisen_US
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Institut Perubatan & Pergigian Termaju - Tesis