Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans

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dc.contributor.authorCheah, Hong Leong
dc.date.accessioned2019-07-12T02:37:09Z
dc.date.available2019-07-12T02:37:09Z
dc.date.issued2014-06
dc.description.abstractCandida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle. The lead compounds identified are caffeic acid, rosmarinic acid and apigenin, which were previously undervalued, but demostrated to have antifungal activity against C. albicans when assayed under physiologically relevant conditions, and have inhibitory property on isocitrate lyase (ICL) enzyme activity.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8470
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectCandida albicans is an opportunistic pathogenen_US
dc.subjecthat causes candidiasis in humanen_US
dc.titleScreening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicansen_US
dc.typeThesisen_US
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