Calcium phosphate-multiwalled carbon nanotubes composites for injectable bone substitute
| dc.contributor.author | Low, Kah Ling | |
| dc.date.accessioned | 2016-11-02T02:46:18Z | |
| dc.date.available | 2016-11-02T02:46:18Z | |
| dc.date.issued | 2011-02 | |
| dc.description.abstract | Calcium phosphate cements (CPCs) has shown very good performance as bone substitute material without any side effects for both in vitro and in vivo. However, these CPCs suffer from a relatively low compressive strength, limiting its applicability in orthopedics. Therefore, the aim of this project is to develop the injectable bone substitute (IBS) consisting of CPCs with different types of multiwalled carbon nanotubes (MWCNTs) and bovine serum albumin (BSA) to. create CPCIMWCNTs/BSA composites with the purpose of improving the mechanical properties of the pure CPCs. The presence of MWCNTs and BSA were found to have significant effects in influencing the morphology of hydroxyapatite (HA) crystals in CPCs matrix. BSA was found to act as promoter for HA growth when bounded to the surface of CPCs grains. Thus, the addition of MWCNTs and BSA could lead to an improvement of compressive strength by modifying the properties of the crystallites. In order to have a systematic process study, design of experiment (DOE) coupled with response surface methodology (RSM) and central composite design (CCD) was used to investigate the relationship between the compressive strength of the composites with the process parameters studied, which was then used for the optimization process. Compressive strength tests, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and injectability tests were used to evaluate the composites properties. Characterization results showed that CPCs composites containing hydroxyl group functionalized MWCNT (MWCNT-OH) and BSA exhibited the highest compressive strength (60 MPa) after 28 days immersion in simulated body fluid (SBF). | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/2956 | |
| dc.subject | Calcium phosphate cements (CPCs) has shown very good performance | en_US |
| dc.subject | as bone substitute material without any side effects | en_US |
| dc.title | Calcium phosphate-multiwalled carbon nanotubes composites for injectable bone substitute | en_US |
| dc.type | Thesis | en_US |
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