The Preparation And Tile Dnug Release Of Polystyrene Microcapsul]S Containing Aqueous Soluble Drug
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Date
1981-02
Authors
SELAMAT, ABDUL GHAPOR
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Abstract
The Preparation and The ~)tudy of The Dr.lg
Release ot ?olystyrene Hicrocapsules contai.."ling Aqueous Soluble Jrug.
It consis~",: of t"v() 1.1~jor ~n.rts. Firstly was the study of The :::f.fect
of ::)tirring on The Size}f The ?l"~crocapsules a.nd The Surf":lce Pore .:!urin.,,!
preparation. Seco.ndly was The Study ot The Release Pattern of The
:l!icroe2.psules with Different Pore Sizes.
The detail Investl,r.atlon WAS done on polY'~tyre!le miC1'Ocapsules
containing sodium salye,ylnte as the 2ctive In~dients.~s 'AaS prepared
the method of evn?orating me~~lene chlori~e f~ an aqueous system.
The shape of the woi"~f';psules WA.S spherlc:tl and .free nowir.g. The !)resenc~
of some tine bubbles and nome ,ockmark-li!:e holes vas ob~er-.red on the
surface of ~~, capsules by the m1croscopic studies. the existence of
holes was ohviously p,onfi~pd by studies on the release 9attern tram the
dissolution test.
The ,lot ot cumUlative percent~e of sodi~ s~licyl~te di~solved
versus ti.":le was done. There were three '~~nses ot din::::olutlon cha~cter1st1c
observed. Initially there was a ~~id rele~se followed by n ~du~l
fall in the ~te ~d finally it plateaued of!. In eeneral the rate of
dissolut~on incre~sed ~s the rate ~f 9tirrin~ Wns increased.In ~~other
as:"lect the rate ot dissolution .llso increa.sed as the ~te of drJing ~las
-f~ed on the:1Ore 91?C'
Incr~ased. ':'he latter ""as probahly due to the 1ncre -' .
of th~ micro~~n~ulcne
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The Preparation And Tile Dnug Release Of , Polystyrene Microcapsul]S Containing Aqueous Soluble Drug