Design And Synthesis Of New 1,2,3- Triazole Dariavatives As Potential Human Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain 2 (PHD2) Inhibitors
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Date
2017-05
Authors
Cheah, June Sun
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Journal ISSN
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Publisher
Universiti Sains Malaysia
Abstract
A series of 1,2,3-triazole based compounds were desingned and their binding modes and free anargies of binding to the prolyl hydroxylase domain 2 (PHD2) active site were evaluated using molecular docking studies by AutoDock 4.0,1. The molecular docking studies demonstrated that the designed compounds were capable of binding to the PHD2 active site in a bidentate manner and forming hydrogen bonding interaction with amino acid residue Arg 383 apart from displaying preferential free energies of binding.
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Keywords
Design and synthesis of new 1,2,3- triazole dariavatives , as potential human hypoxia inducible factor