Design And Synthesis Of New 1,2,3- Triazole Dariavatives As Potential Human Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain 2 (PHD2) Inhibitors
| dc.contributor.author | Cheah, June Sun | |
| dc.date.accessioned | 2018-02-08T01:25:05Z | |
| dc.date.available | 2018-02-08T01:25:05Z | |
| dc.date.issued | 2017-05 | |
| dc.description.abstract | A series of 1,2,3-triazole based compounds were desingned and their binding modes and free anargies of binding to the prolyl hydroxylase domain 2 (PHD2) active site were evaluated using molecular docking studies by AutoDock 4.0,1. The molecular docking studies demonstrated that the designed compounds were capable of binding to the PHD2 active site in a bidentate manner and forming hydrogen bonding interaction with amino acid residue Arg 383 apart from displaying preferential free energies of binding. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/5494 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Design and synthesis of new 1,2,3- triazole dariavatives | en_US |
| dc.subject | as potential human hypoxia inducible factor | en_US |
| dc.title | Design And Synthesis Of New 1,2,3- Triazole Dariavatives As Potential Human Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain 2 (PHD2) Inhibitors | en_US |
| dc.type | Thesis | en_US |
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