Rbc Parameters, Vitamin B12, Folate, Homocysteine Levels And Mthfr Gene Polymorphism In Postmenopausal Malay Women And Their Relation To Hormone Replacement Therapy

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Date
2011
Authors
Alfattah Al Jabr, Mohamed Talal Abd
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Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Hyperhomocysteinemia occurs as a result of decreased levels of cofactors (vitamin B6, vitamin B12 and folate) and/or reduced efficiency of Methylenetetrahydrofolate reductase (MTHFR) enzyme. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and may be one of the factors predisposing for coronary heart disease (CHD) in postmenopausal women. It is not well known whether changes in red blood cells parameters can occur independently of B12 and folate abnormalities in postmenopausal women in association with hyperhomocysteinemia.
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Keywords
Postmenopausal Malay Women , Hormone Replacement Therapy
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