Antioxidant Status And The Effect Of Tocotrienol-Rich-Fraction (Trf) Supplementation On The Antioxidant Enzymes And Development Of Hypertension In Spontaneously Hypertensive Rats (Shr)
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Date
2010-06
Authors
Sundaram, Arunkumar
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Although oxidative stress has been implicated in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR), the precise status of antioxidant enzymes (AOE) and a number of other related parameters such as total glutathione (GSH), total anti-oxidant status (TAS) and malondialdehyde (MDA), and plasma levels of α-, δ- and γ- tocotrienol during the development of hypertension remains unclear. This study therefore examined the levels of these in the kidneys of SHR from the age of 2 to 16 weeks, and the effects of tocotrienol-rich-fraction (TRF) supplementation on these and the development of high blood pressure in this species.
Compared to aged-matched WKY rats, catalase (CAT) activity was significantly higher from 2 weeks of age, and gluthathione peroxidase (GPx) activity was significantly lower from 4 weeks of age in SHR. A similar pattern was also evident in the mRNA expressions. TAS levels were significantly higher in 4-, 10-, 12-, and 16-week old SHR while MDA was unchanged except in 16-week old SHR where it was significantly higher. Plasma α-tocotrienol levels were significantly lower from the age of 6 weeks and onwards, while plasma γ-tocotrienol levels were significantly lower at 12- and 16-week old in SHR.
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Keywords
Tocotrienol-Rich-Fraction (Trf) Supplementation , Antioxidant Enzymes And Development Of Hypertension In Spontaneously Hypertensive Rats (Shr)