Antioxidant Status And The Effect Of Tocotrienol-Rich-Fraction (Trf) Supplementation On The Antioxidant Enzymes And Development Of Hypertension In Spontaneously Hypertensive Rats (Shr)

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dc.contributor.authorSundaram, Arunkumar
dc.date.accessioned2018-10-31T03:00:25Z
dc.date.available2018-10-31T03:00:25Z
dc.date.issued2010-06
dc.description.abstractAlthough oxidative stress has been implicated in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR), the precise status of antioxidant enzymes (AOE) and a number of other related parameters such as total glutathione (GSH), total anti-oxidant status (TAS) and malondialdehyde (MDA), and plasma levels of α-, δ- and γ- tocotrienol during the development of hypertension remains unclear. This study therefore examined the levels of these in the kidneys of SHR from the age of 2 to 16 weeks, and the effects of tocotrienol-rich-fraction (TRF) supplementation on these and the development of high blood pressure in this species. Compared to aged-matched WKY rats, catalase (CAT) activity was significantly higher from 2 weeks of age, and gluthathione peroxidase (GPx) activity was significantly lower from 4 weeks of age in SHR. A similar pattern was also evident in the mRNA expressions. TAS levels were significantly higher in 4-, 10-, 12-, and 16-week old SHR while MDA was unchanged except in 16-week old SHR where it was significantly higher. Plasma α-tocotrienol levels were significantly lower from the age of 6 weeks and onwards, while plasma γ-tocotrienol levels were significantly lower at 12- and 16-week old in SHR.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6935
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectTocotrienol-Rich-Fraction (Trf) Supplementationen_US
dc.subjectAntioxidant Enzymes And Development Of Hypertension In Spontaneously Hypertensive Rats (Shr)en_US
dc.titleAntioxidant Status And The Effect Of Tocotrienol-Rich-Fraction (Trf) Supplementation On The Antioxidant Enzymes And Development Of Hypertension In Spontaneously Hypertensive Rats (Shr)en_US
dc.typeThesisen_US
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