The role of dehydroepiandrosterone sulfate on learning and memory in rat hippocampus and its link to the prefrontal cortex
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Date
2020-10
Authors
Shaimi, Asma Ulhusna
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
simultaneously visualised and imaged in real time imaging with FFM probe connected
to Cell Visio Lab system. The animals were dissected and their hippocampi were
collected for the histological validation of the probe placement using hematoxylin and
eosin (H&E) staining. The conjugation of fluorescent-labelled was the first successful
report which demonstrated the degree of labelling (DOL) in the range of desired results
and showed the signal of DHEAS expression on the FFM connected to the Cell Visio
Lab system. Optimisation on surgical implantation was made to determine the
coordinates at the CA1 area of hippocampus precisely and accurately. The results in
MWM test indicated that both groups (group IIa and IIb) showed significant changes
for spatial learning and memory with enhancement of DHEAS fluorescence intensity.
The results revealed that DHEAS fluorescence intensity significantly increased due to
spatial learning and memory performance. In the 5-CSRTT test, the results exhibited
that the animals learned and tended to respond in an appropriate aperture. The results
indicated attentional performance occurred and integrated with increase in the intensity
of DHEAS fluorescence. Findings form this study were able to elucidate the role of
DHEAS and the association between DHEAS with learning and memory
performances as well as executive function thus linking the CA1 area of the
hippocampus to the prefrontal cortex.
Description
Keywords
Dehydroepiandrosterone