The role of dehydroepiandrosterone sulfate on learning and memory in rat hippocampus and its link to the prefrontal cortex

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dc.contributor.authorShaimi, Asma Ulhusna
dc.date.accessioned2021-01-13T01:29:29Z
dc.date.available2021-01-13T01:29:29Z
dc.date.issued2020-10
dc.description.abstractsimultaneously visualised and imaged in real time imaging with FFM probe connected to Cell Visio Lab system. The animals were dissected and their hippocampi were collected for the histological validation of the probe placement using hematoxylin and eosin (H&E) staining. The conjugation of fluorescent-labelled was the first successful report which demonstrated the degree of labelling (DOL) in the range of desired results and showed the signal of DHEAS expression on the FFM connected to the Cell Visio Lab system. Optimisation on surgical implantation was made to determine the coordinates at the CA1 area of hippocampus precisely and accurately. The results in MWM test indicated that both groups (group IIa and IIb) showed significant changes for spatial learning and memory with enhancement of DHEAS fluorescence intensity. The results revealed that DHEAS fluorescence intensity significantly increased due to spatial learning and memory performance. In the 5-CSRTT test, the results exhibited that the animals learned and tended to respond in an appropriate aperture. The results indicated attentional performance occurred and integrated with increase in the intensity of DHEAS fluorescence. Findings form this study were able to elucidate the role of DHEAS and the association between DHEAS with learning and memory performances as well as executive function thus linking the CA1 area of the hippocampus to the prefrontal cortex.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/10826
dc.language.isoenen_US
dc.publisherPusat Pengajian Sains Perubatan, Universiti Sains Malaysiaen_US
dc.subjectDehydroepiandrosteroneen_US
dc.titleThe role of dehydroepiandrosterone sulfate on learning and memory in rat hippocampus and its link to the prefrontal cortexen_US
dc.typeThesisen_US
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