Substituted Apatite/Poly-Epsiloncaprolactone Biocomposite As Substrates And Coating On Alphatricalcium Phosphate Foams
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Date
2013-05
Authors
Bang, Le Thi
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
In this research, carbonate and silicon-substituted apatite/poly-ɛ-caprolactone
biocomposite were produced to be used as a porous biocomposite bone substitute.
Carbonate apatite/poly-ɛ-caproplactone (CO3Ap/PCL) was also used to coat on a
fully interconnected structure of α-tricalcium phosphate (α-TCP) foam to enhance the
mechanical and biological properties, and to mimic the structure of cancellous bone.
Carbonate apatite (CO3Ap) and silicon-substituted carbonate apatite (Si-CO3Ap)
were synthesized by a precipitation method. The results revealed that the silicate and
carbonate ions competed to occupy the phosphate site and also entered
simultaneously into the hydroxyapatite structure. The Si-substituted CO3Ap reduced
the powder crystallinity and promoted ion release which resulted in a better solubility
compared to that of Si-free CO3Ap. The silicon and carbonate co-substitution
appeared to have a better effect on the early stages of osteoblast behavior (cell
attachment and proliferation) rather than the immediate/late stages (proliferation and
differentiation). The fabrication of a biocomposite derived from an interconnected
porous Si-CO3Ap reinforced with molten poly-ε-caprolactone (PCL) was then
developed to mimic the composition and structure of bone coupled with enhanced
mechanical performance. Porous silicon-substituted carbonate apatite blocks were
produced using wax as a volatile agent. The interconnected porous Si-CO3Ap
obtained has a porosity of about 80% and a pore size of about 100-200 μm.
Description
Keywords
Apatite/Poly-Epsiloncaprolactone Biocomposite , Substrates And Coating On Alphatricalcium Phosphate Foams