Substituted Apatite/Poly-Epsiloncaprolactone Biocomposite As Substrates And Coating On Alphatricalcium Phosphate Foams

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dc.contributor.authorBang, Le Thi
dc.date.accessioned2019-02-14T04:22:41Z
dc.date.available2019-02-14T04:22:41Z
dc.date.issued2013-05
dc.description.abstractIn this research, carbonate and silicon-substituted apatite/poly-ɛ-caprolactone biocomposite were produced to be used as a porous biocomposite bone substitute. Carbonate apatite/poly-ɛ-caproplactone (CO3Ap/PCL) was also used to coat on a fully interconnected structure of α-tricalcium phosphate (α-TCP) foam to enhance the mechanical and biological properties, and to mimic the structure of cancellous bone. Carbonate apatite (CO3Ap) and silicon-substituted carbonate apatite (Si-CO3Ap) were synthesized by a precipitation method. The results revealed that the silicate and carbonate ions competed to occupy the phosphate site and also entered simultaneously into the hydroxyapatite structure. The Si-substituted CO3Ap reduced the powder crystallinity and promoted ion release which resulted in a better solubility compared to that of Si-free CO3Ap. The silicon and carbonate co-substitution appeared to have a better effect on the early stages of osteoblast behavior (cell attachment and proliferation) rather than the immediate/late stages (proliferation and differentiation). The fabrication of a biocomposite derived from an interconnected porous Si-CO3Ap reinforced with molten poly-ε-caprolactone (PCL) was then developed to mimic the composition and structure of bone coupled with enhanced mechanical performance. Porous silicon-substituted carbonate apatite blocks were produced using wax as a volatile agent. The interconnected porous Si-CO3Ap obtained has a porosity of about 80% and a pore size of about 100-200 μm.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7729
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectApatite/Poly-Epsiloncaprolactone Biocompositeen_US
dc.subjectSubstrates And Coating On Alphatricalcium Phosphate Foamsen_US
dc.titleSubstituted Apatite/Poly-Epsiloncaprolactone Biocomposite As Substrates And Coating On Alphatricalcium Phosphate Foamsen_US
dc.typeThesisen_US
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