A Hospital-Based Case-Control Study Of Factors Associated With Colorectal Cancer
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Date
2016-08
Authors
Rosdi, Aminu Aisyahtun
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Colorectal cancer (CRC) was the second most common cancer in Malaysia after
breast cancer. The incidence rates of CRC for both male and female had been
reported increasing. This study was conducted to determine the associated factors of
CRC in selected hospitals in Malaysia. A hospital-based case-control study of 128
cases and 128 controls was carried out by using a validated questionnaire.
Participants who fulfilled the inclusion and exclusion criteria were included as the
case and control groups accordingly. Multiple logistic regression was used for data
analysis. The mean age of CRC was 59.84 years old (standard deviation 11.20).
Majority of CRC was males (60.9%) and Malay race (57.8%). The significant factors
associated with CRC were age equal and more than 55 years old [Adjusted Odds
Ratio (AOR): 4.54; 95% confidence interval (CI): 2.45-8.40; p value <0.001],
Chinese ethnicity [AOR: 6.67; 95% CI: 2.01-22.13; p value = 0.002], family history
of CRC [AOR: 11.26; 95% CI: 3.02-41.94; p value <0.001], history of polyps [AOR:
5.45; 95% CI: 1.94-15.28; p value <0.001], and ever smoker [AOR: 3.40; 95% CI:
1.63-7.10; p value <0.001]. As a conclusion, factors significantly associated with
CRC are older age, chinese ethnicity, family history of CRC, history of polyps and
ever smoked. These factors could be used as a reference to guide the people and
Ministry of Health on risk factors to get CRC, adopting a healthy lifestyle in order to
decrease the incidence of CRC in Malaysia.
Description
Keywords
Colorectal cancer was the second , most common cancer in Malaysia.