Kesan minyak esensial citrus SPP ke atas sistem kardiovaskular tikus serta kesan antiresah dan antidepresi pada mencit
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Date
2007
Authors
Che Awang, Che Rugayah
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Abstract
This study attempts to look at the effects of three essential oils from
members of the Citrus family of plants on the cardiovascular system of the rats
and to look at possible antianxiety and antidepressive effects of these oils. It's
balmy smell suggest that these essential oils could produce relaxation possibly via
its action on the central nervous system and subsequently may influence indirectly
the cardiovascular system. The study focused on the effects of essential oils of
Citrus spp on the blood pressure and heart rate of rats (the effect of direct aroma
test via the nasal passage), and the antianxiety and antidepressive effects of
these essential oils in mice. The results obtained may be correlated to the effects
seen on human emotion (Elevated Plus-maze test and Behavioral Despair or
Forced Swimming test). Essential oils of 3 members of the Citrus genus from the
Rutaceae family were used. Specifically they are the Citrus hystrix, D. C. (wild lime
or 'limau purut'), Citrus microcarpa (musk lime or 'limau kasturi') and Citrus
aurantifolia (common lime or 'limau nipis'). These plants are traditionally used as
medicaments by Malays, perhaps due to its strong and characteristic smell.
Intranasal C. hystrix shows significant hypotensive (p < 0.05) on the blood
pressure (systolic and dystolic) with sustained hypotensive for 5.30 ± 5.5 minutes,
but for the heart rate of the rats, it is not significantly (p > 0.05) different. Results
from our experiment showed the smelling of essential oils (0.1 ml) of C. hystrix
and C. microcarpa conffered antianxiety and C. aurantifolia has antidepressive
properties. The thesis describes the effects of essential oils of the three Citrus spp
and suggestions as to the possible mode of action of these oils on the
cardiovascular system and the central nerve system.
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Keywords
Esensial Citrus SPP , Kardiovaskular tikus , Antidepresi