The Effects Of Angiotensin Iconverting Enzyme (ACE) I/D And Alphaactinin- 3 (ACTN3) R/X Gene Polymorphisms On Human Physical Performance And Health Within Malaysian Population
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Date
2016-02
Authors
Yusof @ Hanafi, Hazwani Ahmad
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
A disparity population data set in the current literature with limited reports
among Asian samples, coupled with the inconsistent findings among different ethnic
groups, and lack of information for the involvement of angiotensin I-converting
enzyme (ACE) I/D and alpha-actinin-3 (ACTN3) R/X gene polymorphisms in training
adaptation have limited the ability of researchers to draw meaningful conclusions
pertaining to the effects of these polymorphisms on human physical performance and
health. Therefore, this doctoral research implemented three series of studies to
examine the effects of ACE I/D and ACTN3 R/X gene polymorphisms on human
physical performance and health within the Malaysian population. In the first study,
DNA samples were retrieved via buccal cell from 180 Asians from Malaysia (70
males, 110 females) aged 20.4 ± 1.6 years, and 180 Caucasians from Australia (62
males, 118 females) aged 23.3 ± 3.6 years. In the second study, DNA samples were
retrieved from 180 well-trained Malaysian athletes (148 males, 32 females) aged
20.5 ± 1.9 years, 180 Malaysian sedentary controls, and 33 intermittent Australian
athletes (all males) aged 20.7 ± 4.0 years. Endurance and muscular performances of
Malaysian athletes were evaluated with 20 meters Yo-Yo intermittent recovery level
2 and maximal voluntary contraction tests, respectively. In the third study, thirty
normotensive, untrained males (ACE genotype: II = 10, ID = 10, and DD = 10),
undergone isometric handgrip training (four sets of 2 minutes isometric contractions
at 30% of maximal voluntary contraction, with 1 minute resting interval) 3 days per
week for 8 weeks.
Description
Keywords
The effects of angiotensin i-converting enzyme , on human physical performance