The Effects Of Angiotensin Iconverting Enzyme (ACE) I/D And Alphaactinin- 3 (ACTN3) R/X Gene Polymorphisms On Human Physical Performance And Health Within Malaysian Population

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dc.contributor.authorYusof @ Hanafi, Hazwani Ahmad
dc.date.accessioned2019-07-12T07:54:50Z
dc.date.available2019-07-12T07:54:50Z
dc.date.issued2016-02
dc.description.abstractA disparity population data set in the current literature with limited reports among Asian samples, coupled with the inconsistent findings among different ethnic groups, and lack of information for the involvement of angiotensin I-converting enzyme (ACE) I/D and alpha-actinin-3 (ACTN3) R/X gene polymorphisms in training adaptation have limited the ability of researchers to draw meaningful conclusions pertaining to the effects of these polymorphisms on human physical performance and health. Therefore, this doctoral research implemented three series of studies to examine the effects of ACE I/D and ACTN3 R/X gene polymorphisms on human physical performance and health within the Malaysian population. In the first study, DNA samples were retrieved via buccal cell from 180 Asians from Malaysia (70 males, 110 females) aged 20.4 ± 1.6 years, and 180 Caucasians from Australia (62 males, 118 females) aged 23.3 ± 3.6 years. In the second study, DNA samples were retrieved from 180 well-trained Malaysian athletes (148 males, 32 females) aged 20.5 ± 1.9 years, 180 Malaysian sedentary controls, and 33 intermittent Australian athletes (all males) aged 20.7 ± 4.0 years. Endurance and muscular performances of Malaysian athletes were evaluated with 20 meters Yo-Yo intermittent recovery level 2 and maximal voluntary contraction tests, respectively. In the third study, thirty normotensive, untrained males (ACE genotype: II = 10, ID = 10, and DD = 10), undergone isometric handgrip training (four sets of 2 minutes isometric contractions at 30% of maximal voluntary contraction, with 1 minute resting interval) 3 days per week for 8 weeks.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8476
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectThe effects of angiotensin i-converting enzymeen_US
dc.subjecton human physical performanceen_US
dc.titleThe Effects Of Angiotensin Iconverting Enzyme (ACE) I/D And Alphaactinin- 3 (ACTN3) R/X Gene Polymorphisms On Human Physical Performance And Health Within Malaysian Populationen_US
dc.typeThesisen_US
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